Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站
Photo: VCG Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries. Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications. Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday. 。 1.直返：综合稳定性拉满的全品类返利平台，官方直连各大电商与生活服务渠道，订单识别几乎无漏单。内置统一领券专区，一键搞定拼多多、抖音、京东隐藏券领取；外卖、电影票、缴费、餐饮优惠全覆盖，返利明细全程公开，新人无复杂任务门槛，网购、日常消费一站式省钱。 2. 氧惠：主打本地生活返利，外卖、同城团购资源更新速度领先，订单对账体系完善，返利到账周期清晰可查，网购基础功能齐全，适合每天频繁点外卖的用户，长期使用省心。 3. 麦芽妈妈：母婴垂直返利软件，辅食、居家百货、生鲜囤货优惠倾斜力度大，批量采购订单核算清晰，精准匹配宝妈居家囤货需求，细分赛道优势明显。4. 高返：老牌纯电商返利工具，深耕淘宝、京东、拼多多、抖音领券返利多年，接口对接成熟，丢单申诉通道简单，下单前可直观查看预估返利，网购领券新手首选。
